Despite progress in cancer biology, deciphering the spatial architecture of the tumor microenvironment remains a challenge. Traditional approaches lack the resolution to map cell-type-specific gene ...

A spatial atlas maps pancreatic tumor cell identity and location, illuminating potential treatment pathways for pancreatic ductal adenocarcinoma. An international collaboration led by researchers at ...

Single-cell studies have identified a series of critical cell subsets, including lymphocytes, myeloid cells, stromal cells, and nerve-related cells, within the tumor microenvironment (TME). These ...

In a study published in Science, researchers from The University of Texas MD Anderson Cancer Center have developed a spatial atlas of specialized immune structures, called tertiary lymphoid structures ...

Larotrectinib in Patients With Tumors With NTRK Fusions: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol EAY131-Z1E Advancements in profiling technologies have deepened our ...

Antigen presentation suppression as a hallmark of immune evasion and poor outcomes in small cell lung cancer. IMforte: Quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis of ...

Cancer behaves as a complex, evolving system in which interactions between malignant cells and their surrounding environment shape growth, adaptation, and resistance to therapy. This understanding ...

The inflammatory tumor microenvironment (TME) is a complex network of cancer, immune, and stromal cells interacting through cytokines and growth factors to drive tumor growth, angiogenesis, and immune ...

One of the most detailed maps to date of meningioma, the most common brain tumor in adults, reveals how the tumor’s ...

Abbreviations: i, Inhibitor/antagonist; α, Anti (e.g., αCCR4, anti-CCR4 antibody); Ab, Antibody; mAb, Monoclonal antibody;­ ↑, Enhance/increase; TME, Tumor ...