Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...

A new purpose-built microscope has been developed that uses the complex properties of UV light to improve image resolution and contrast. Most cells are transparent at visible wavelengths, which means ...