However,instead of attacking cancer cells, they are typically co-opted to support tumor growth, metastasis, and therapeutic ...

Significant opportunities in the cancer metabolism-based therapeutics market include leveraging precision medicine to target unique cancer cell metabolic pathways, driving personalized treatment ...

Metabolic reprogramming is a defining hallmark of breast cancer, encompassing diverse alterations in energy utilisation, biosynthetic pathways and intracellular signalling. Tumour cells frequently ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

AbstractNon apoptotic cell death programs particularly ferroptosis and cuproptosis are transforming how we understand cancer ...

Tumor-associated macrophages (TAMs) are immune cells that tumors hijack to fuel their own growth and evade immune attack. A ...

Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...

Breast cancer development is not solely the result of cancer cells acting independently, it involves a dynamic and complex ecosystem composed of cancer cells, immune cells, fibroblasts, adipocytes, ...

People with obesity and type 2 diabetes are at high risk of blood vessel damage. This risk depends not only on the genes a person carries, but also on how they are "read." By changing the epigenetic ...

Breast cancer remains the most prevalent malignancy among women worldwide, posing a critical challenge to global health. Amid the complexities of this disease, an emerging focus on metabolic ...

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...