Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] A major mechanistic influence on aging ...

Margarita Behrens (left) and Joseph Ecker (right) published an atlas of the cell type-specific epigenetic changes that occur in the mouse brain as it ages, which will propel neurodegenerative disease ...

Stanford scientists found that aging disrupts the brain’s internal navigation system in mice, mirroring spatial memory decline in humans. Older mice struggled to recall familiar locations, while a few ...

Aging is associated with progressive white matter degeneration, which impairs brain structure and function. Defects in myelinating glial cells, combined with chronic neuroinflammation, contribute to ...

Salk researchers used spatial transcriptomics to map where different cell types reside in the mouse brain. Shown are excitatory neurons (left, blue), inhibitory neurons (middle, red), and non-neuronal ...

While such advances bring with them a breadth of knowledge, the immense complexity of the datasets makes it challenging for scientists to analyze them using current computational methods. Now, ...

At the turn of the 20th century, Korbinian Brodmann released one of the most consequential brain maps ever. By studying the humps, grooves, layers, and cells of the cortex—the outermost layer of the ...

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...